Description
The fastest-growing premium bone-support supplement formulation combining Vitamin D3 (cholecalciferol) for calcium absorption with Vitamin K2 (menaquinone-7) for proper calcium directional metabolism into bone rather than soft tissue.
Pale yellow to amber oily concentrate or free-flowing white to pale yellow powder (microencapsulated). Light- and oxidation-sensitive; requires sealed, light-protective packaging.
We supply supplement-grade D3 + K2 combinations from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production. Custom potency ratios available for private-label and proprietary blends.
Common market grades include D3 + K2 Oil (5000 IU D3 + 100 mcg K2 per gram, the standard supplement concentrate), D3 + K2 Powder (microencapsulated, for dry tablet and capsule applications), Vegan D3 + K2 (lichen-derived D3 paired with fermentation-derived MK-7), and customized ratios for proprietary formulations.
Bulk and reduced-MOQ shipments. Batch-level COA covering D3 potency, K2 (MK-7) content, all-trans K2 isomer percentage, peroxide value, heavy metals, and microbiology.
Introduction
The Vitamin D3 + K2 combination addresses the biological need for both vitamins in proper calcium metabolism: D3 promotes calcium absorption from the gut, while K2 activates the proteins (osteocalcin in bone, matrix Gla protein in soft tissue) that direct absorbed calcium to bone deposition rather than soft-tissue and vascular calcification.
Industrial production proceeds by separate production of Vitamin D3 (catalog id 7890) and Vitamin K2 MK-7 (a fermentation product of Bacillus subtilis natto), followed by precision blending to specified potency ratios. The combination is then either dissolved in MCT or sunflower oil for liquid concentrates or microencapsulated for dry applications.
Approved as a dietary supplement combination by the U.S. FDA and equivalent regulators worldwide. EFSA has issued positive opinions on both vitamins individually and on their combined cardiovascular and bone-health positioning.
Strategic positioning is the premium bone-health and cardiovascular-support segment. Market growth since 2015 has been the strongest of any single supplement formulation, driven by clinical literature supporting both individual vitamins, the cardiovascular calcification concern raised by D3-only supplementation, and the proprietary all-trans MK-7 fermentation technology.
The K2 isomer matters: the all-trans MK-7 form is biologically active and bone-protective, while the cis isomer is essentially inactive. Premium products specify all-trans content at ≥ 98 percent; commodity products may contain up to 30 percent cis isomer with reduced biological efficacy.
Where it is used
- Premium bone-health supplements: the fastest-growing bone-support category since 2015
- Cardiovascular-health supplements (vascular calcification protection positioning)
- Multivitamin formulations in the premium and natural-products segment
- Anti-aging and longevity-positioned supplement blends
- Osteoporosis prevention and management formulations
- Pediatric and prenatal supplements (where appropriate doses are used)
- Functional foods and fortified beverages
- Pharmaceutical adjunct formulations for bone-health indications
Technical data
| Item | Specification |
|---|---|
| Appearance | Pale yellow to amber oil or white to pale yellow powder |
| Vitamin D3 potency | 1,000 IU/g to 100,000 IU/g (grade dependent) |
| Vitamin K2 MK-7 content | 0.1% to 2.0% (grade dependent) |
| All-trans MK-7 isomer | ≥ 98.0% of total MK-7 |
| D3 / K2 ratio | Per customer specification |
| Peroxide value | ≤ 10 meq/kg |
| Heavy metals (as Pb) | ≤ 10 mg/kg |
| Arsenic | ≤ 3 mg/kg |
| Available forms | Oil, microencapsulated powder, vegan variants |
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