Pyridoxal 5'-Phosphate

The active coenzyme form of Vitamin B6, used directly in over 100 amino-acid and neurotransmitter metabolism reactions without the conversion that pyridoxine hydrochloride requires. The premium B6 form for advanced supplement positioning.

Yellow to pale orange crystalline powder. Light- and moisture-sensitive; requires sealed, light-protective packaging. Typical supplement doses are 10 to 50 milligrams.

We supply pharmaceutical-grade and supplement-grade P-5-P from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production.

Common market grades include Pharmaceutical Grade (≥ 98 percent purity) and Supplement Grade (FCC compliant). Available as the monohydrate or anhydrous form depending on application requirements.

Bulk and reduced-MOQ shipments. Batch-level COA covering assay, related substances, water content, phosphate content, heavy metals, and microbiology.

Pyridoxal 5'-phosphate (P-5-P or PLP) is the metabolically active coenzyme form of Vitamin B6. The compound serves as the cofactor for over 100 enzymatic reactions in human metabolism, particularly those involving amino acid transamination, decarboxylation, and synthesis of neurotransmitters including serotonin, dopamine, GABA, and noradrenaline.

Industrial production proceeds by chemical synthesis from pyridoxine through phosphorylation under controlled conditions, followed by crystallization to pharmaceutical specifications. The synthesis preserves the natural stereochemistry of the active coenzyme.

Approved as a Generally Recognized as Safe dietary ingredient by the U.S. FDA and as a permitted vitamin form by EFSA and equivalent regulators. Listed as a pharmaceutical reference standard in USP.

Strategic positioning is premium supplement applications, where the 'active B6' and 'pre-converted' positioning supports substantial price premium over pyridoxine HCl (catalog id 7862). The form is particularly relevant for individuals with impaired hepatic phosphorylation capacity, which can prevent effective conversion of supplemental pyridoxine to the active PLP form.

Clinical use includes treatment of rare B6-dependent epilepsy syndromes in pediatric neurology, where direct administration of P-5-P bypasses defective enzymatic conversion steps and prevents otherwise refractory seizures.

• Premium dietary supplements: active-B6 and methylation-support formulations
• Pharmaceutical applications for B6-dependent epilepsy and specific inborn errors of metabolism
• Hormonal balance and PMS-support supplement formulations
• Neurotransmitter-support supplements (paired with magnesium and zinc)
• Multivitamin formulations in the premium and natural-products segment
• Sports nutrition and protein-utilization formulations
• Functional medicine and integrative health formulations
• Clinical nutrition for B6 dependency syndromes