Pyrroloquinoline Quinone Disodium Salt

A redox cofactor and bioactive compound that stimulates mitochondrial biogenesis through PGC-1α activation. The disodium salt is the stable, water-soluble form used in commercial supplement formulation.

Reddish-brown to dark red crystalline powder. Water-soluble. Stable through standard supplement-manufacturing temperatures when protected from prolonged light exposure.

We supply food-grade Pyrroloquinoline Quinone Disodium Salt from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production. The material is produced by bacterial fermentation followed by purification and salt formation.

Common market grades include 98 percent and 99 percent purity by HPLC. Typical finished-product dosing is 10 to 20 mg per serving, so the ingredient is most often supplied to manufacturers in low-MOQ formats appropriate to its cost basis.

Bulk and reduced-MOQ shipments. Batch-level COA covering assay, related substances, residual solvents, heavy metals, and microbiology.

Pyrroloquinoline Quinone was first identified in 1979 as a bacterial cofactor for methanol dehydrogenase by J. A. Duine and colleagues in the Netherlands. The molecule has since been shown to occur in trace amounts in human breast milk, fermented foods, and a range of plant tissues.

Commercial production is by fermentation using Hyphomicrobium denitrificans or related methylotrophic bacteria, followed by extraction, chromatographic purification, and conversion to the disodium salt for stability and solubility in finished-product formulation.

Approved as a new dietary ingredient by the U.S. FDA under NDI 786 in 2008 (BioPQQ filing) and recognised as a novel food ingredient in the EU following EFSA review. Approved in Japan and China under their respective supplement frameworks.

PQQ acts both as a direct antioxidant capable of approximately 20,000 catalytic redox cycles per molecule (compared to roughly four for ascorbate) and as a signalling molecule that upregulates mitochondrial biogenesis through the PGC-1α and CREB pathways. The combination of these two mechanisms underpins its position in the premium longevity-supplement category.

Typical finished-product dosing is 10 to 20 mg per day, which makes PQQ one of the most cost-intensive ingredients in modern supplement formulation on a per-serving basis. The ingredient is almost always positioned in premium price tiers and is rarely included in mass-market multivitamins.

• Mitochondrial-health and cellular-energy supplements; the leading commercial value proposition for the ingredient
• Cognitive and nootropic formulations; supports nerve growth factor and neuronal protection
• Anti-aging and longevity stacks, often combined with CoQ10, NMN, or NR
• Sports and endurance supplements targeting muscle mitochondrial density
• Sleep-quality and recovery formulations
• Cardiovascular-support supplements as an adjunct to CoQ10
• Premium multivitamin and women's-health formulations
• Functional foods and wellness beverages in the Japanese and Chinese markets