Adenosylcobalamin

The mitochondrial coenzyme form of Vitamin B12, used directly by the methylmalonyl-CoA mutase enzyme in mitochondrial fatty acid and amino acid metabolism. The premium 'energy metabolism' form of B12 for advanced supplement positioning.

Dark red to orange-red crystalline powder. Extremely light-sensitive; requires sealed, opaque packaging and protected storage. Typical supplement and clinical doses are 1 to 10 milligrams.

We supply pharmaceutical-grade and supplement-grade Adenosylcobalamin from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production.

Common market grades include Pharmaceutical Grade (≥ 98 percent purity), Supplement Grade (FCC compliant), and 1 percent triturated dilutions for premix and direct-dosing applications.

Bulk and reduced-MOQ shipments. Batch-level COA covering assay, related cobalamins, water content, heavy metals, and microbiology.

Adenosylcobalamin (also called dibencozide or coenzyme B12) is one of the two naturally occurring metabolically active coenzyme forms of Vitamin B12. The adenosyl form serves as the cofactor for methylmalonyl-CoA mutase, the mitochondrial enzyme responsible for catabolism of branched-chain amino acids and odd-chain fatty acids.

Industrial production proceeds by fermentation of Propionibacterium or Pseudomonas species to yield cyanocobalamin, followed by reductive alkylation with 5'-deoxyadenosine under anaerobic conditions to yield the adenosyl form.

Recognized as a permitted dietary supplement ingredient by the U.S. FDA and most regulators worldwide. Marketed in Italy and several European countries as a prescription pharmaceutical for anabolic and recovery applications since the 1960s.

Strategic positioning is premium supplement and clinical applications, particularly where the energy-metabolism positioning is appropriate. Many advanced active-B12 supplements combine adenosylcobalamin with methylcobalamin to provide both coenzyme forms simultaneously.

The clinical literature supports preferential use of adenosylcobalamin for mitochondrial and energy-positioning applications and for rare inborn errors of B12 metabolism. For routine B12 repletion in healthy individuals, the various B12 forms are biologically equivalent.

• Premium dietary supplements: mitochondrial-support and energy-positioned formulations
• Pharmaceutical applications: oral tablets and injectable preparations
• Active-B12 blends (paired with methylcobalamin for full coenzyme support)
• Anabolic and recovery formulations in the sports nutrition segment
• Functional medicine and integrative health formulations
• Geriatric and chronic fatigue management supplements
• Rare metabolic disorder management (methylmalonic acidemia)
• Veterinary preparations for performance animals