Acetyl Hexapeptide-8 (Argireline)

A synthetic hexapeptide modeled on the N-terminus of SNAP-25, the SNARE-complex protein targeted by botulinum toxin. Positioned as a topical expression-line peptide with documented in vivo reduction in periocular and forehead wrinkle appearance over 12 to 28 days of twice-daily application.

Off-white to pale yellow powder, typically supplied as a 0.05 percent solution in water with preservative (the trade-standard delivery form known by the Lipotec trademark Argireline). Fully water-soluble in the diluted form, with stability across pH 5 to 7 in finished products.

We supply cosmetic-grade Acetyl Hexapeptide-8 from manufacturers in China holding ISO 22716, ISO 9001, Halal and Kosher certifications relevant to the product and production. Both powder and solution forms are available.

Common market grades include Acetyl Hexapeptide-8 Solution at 0.05% (the standard finished-ingredient form for direct cosmetic use), 95% min powder for premium and concentrated applications, and 99% min HPLC-purified powder for clinical-grade serums.

Bulk and reduced-MOQ shipments. Batch-level COA covering HPLC purity, amino acid analysis, related peptides, residual TFA, heavy metals, and microbiology.

Acetyl Hexapeptide-8 was developed by Lipotec (now Lubrizol) in Spain in the early 2000s and trademarked as Argireline. The peptide sequence is Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2, designed to mimic the N-terminus of SNAP-25 and competitively inhibit the SNARE complex required for neurotransmitter release at the neuromuscular junction.

Industrial production is by solid-phase peptide synthesis (SPPS) using Fmoc chemistry, followed by HPLC purification, lyophilization, and dilution into the aqueous trade form. The peptide market has expanded from premium-only positioning to mass-tier serums as manufacturing capacity has grown.

Regulatory status is that of a listed cosmetic ingredient in CosIng, the PCPC INCI dictionary, and China IECIC. No concentration limit in major jurisdictions; typical use is 5 to 10 percent of the 0.05% solution form (delivering 25 to 50 ppm active peptide) in finished products.

Clinical evidence is mixed but commercially decisive. The Lipotec-sponsored clinical work shows measurable in vivo reduction in wrinkle depth and area at 10 percent solution over 28 days. Independent literature is smaller in volume and more cautious, but the ingredient has accumulated nearly two decades of market presence with consumer-perceived effect.

Strategically, Acetyl Hexapeptide-8 is the founding ingredient of the cosmetic peptide category and remains the most-formulated synthetic peptide in anti-aging serums globally. It is typically blended with palmitoyl peptides for matrix support and copper peptides for repair claims.

• Expression-line serums positioned around crow's feet and forehead lines
• Anti-aging eye contour creams and concentrates
• Topical pre-injection and between-treatment products in aesthetic clinics
• Combination peptide blends with palmitoyl pentapeptide-4 (Matrixyl) and copper peptides
• Lip plumping and lip line treatments
• Neck and decolletage anti-aging products
• Sheet masks and ampoules positioned around immediate smoothing
• Premium night creams and sleeping masks