Description
Calcium hydrogen phosphate, supplied in both anhydrous (CaHPO4) and dihydrate (CaHPO4·2H2O) forms. The dihydrate is the dominant food and pharmaceutical grade; the anhydrous form is preferred in moisture-sensitive direct-compression tableting.
White, odorless, free-flowing powder. Practically insoluble in water, soluble in dilute hydrochloric acid. The dihydrate transforms to anhydrous above 100 °C, which is the basis for the moisture sensitivity of high-dose tablet formulations.
We supply food-grade, feed-grade, and pharmaceutical-grade Dicalcium Phosphate from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production.
Common market grades include food-grade dihydrate for fortification, USP/EP/JP pharmaceutical dihydrate for direct compression, anhydrous pharmaceutical grade for moisture-sensitive tablet formulations, and feed grade for animal nutrition. Specialized milled grades support specific tablet hardness and dissolution requirements.
Bulk and reduced-MOQ shipments. Batch-level COA covering calcium, phosphorus, fluoride, heavy metals, and microbiology.
Introduction
Dicalcium Phosphate occurs naturally in dental enamel and in some bone mineral deposits. Industrial production for food, pharmaceutical, and feed use is synthetic, made by reacting phosphoric acid with calcium hydroxide or calcium carbonate at controlled pH to yield the mono-hydrogen calcium phosphate intermediate.
The dihydrate (CaHPO4·2H2O), known by the mineralogical name brushite, is the form most commonly supplied for food and pharmaceutical applications. The anhydrous form (monetite) is preferred where moisture migration from the excipient into a moisture-sensitive active ingredient must be avoided.
Regulated in the EU as E341(ii) within the calcium phosphates group, classified as Generally Recognized as Safe by the U.S. FDA under 21 CFR 184.1217, listed in USP, EP, and JP monographs, and approved by JECFA within the calcium phosphates group ADI framework.
In finished products, the dihydrate functions as a free-flowing tablet filler with excellent compression behavior and predictable disintegration in gastric pH. The phosphorus and calcium content contribute to nutritional fortification claims in food applications, while in tablets the role is primarily structural rather than active.
Strategic positioning: Dicalcium Phosphate is the workhorse calcium-phosphorus salt of the global tablet industry and a major fortification ingredient. Selection of dihydrate versus anhydrous, plus mesh and bulk density, determines whether a given grade performs well in a specific tableting line.
Where it is used
- Direct-compression tablet excipient in nutraceutical and pharmaceutical tablets; one of the most widely used filler-binders globally
- Calcium and phosphorus fortification in breakfast cereals, infant formula, beverages, and supplement bars
- Dough conditioner and yeast nutrient in commercial baking
- Toothpaste abrasive in the dihydrate form; one of the original toothpaste polishing agents
- Animal feed and pet food mineral premixes; primary source of supplemental phosphorus in livestock nutrition
- Pharmaceutical tablet filler in chewable calcium supplements and multivitamins
- Bulking agent and carrier in vitamin and mineral premixes
- Stabilizer in some processed-cheese and dairy applications
Technical data
| Item | Specification |
|---|---|
| Appearance | White free-flowing powder |
| Assay (CaHPO4·2H2O, dry basis) | 98.0% to 105.0% |
| Calcium content | 23.0% to 25.0% |
| Phosphorus content (as P) | 17.5% to 18.5% |
| Loss on ignition (800 °C) | 24.5% to 26.5% (dihydrate) |
| pH (10% suspension) | 6.5 to 7.5 |
| Fluoride | ≤ 50 mg/kg |
| Heavy metals (as Pb) | ≤ 10 mg/kg |
| Arsenic | ≤ 3 mg/kg |
| Particle size | Per customer specification |
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