Description
A non-essential amino acid with a distinctive cyclic structure. Used in collagen and connective-tissue supplements, in pharmaceutical applications, and in the synthesis of pharmaceutical and food chemicals.
White crystalline powder. Highly water-soluble. Distinct from other amino acids by its secondary amine structure (the only proteinogenic amino acid with this feature).
We supply food-grade and pharmaceutical-grade L-Proline from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production.
Common market grades include Standard Food Grade (FCC compliant), Pharmaceutical Grade meeting BP/USP/EP/JP specifications, and pre-blended Proline with Lysine and Vitamin C for collagen-support supplement formulations.
Bulk and reduced-MOQ shipments. Batch-level COA covering assay, specific rotation, related amino acids, heavy metals, and microbiology.
Introduction
L-Proline is a non-essential amino acid that the body produces from glutamate. The molecule has a unique cyclic structure where the side chain attaches to both the alpha-carbon and the nitrogen, producing the only secondary-amine proteinogenic amino acid.
Industrial production proceeds by submerged aerobic fermentation using Corynebacterium glutamicum or Escherichia coli strains.
Recognized as a permitted food ingredient by the U.S. FDA, the European Food Safety Authority, and equivalent regulators worldwide. Listed in BP, USP, EP, and JP pharmacopoeias.
L-Proline is one of the most abundant amino acids in collagen (along with glycine and hydroxyproline), accounting for approximately 17 percent of collagen amino acid composition. This underpins the supplement positioning for collagen-support, joint-health, and beauty-from-within applications.
Strategic positioning serves the rapidly growing beauty-from-within and joint-health supplement segments, often co-formulated with glycine, lysine, and Vitamin C for combined collagen-support claims. Pharmaceutical applications include parenteral nutrition and drug-synthesis feedstock for ACE inhibitor manufacturing.
Where it is used
- Collagen-support dietary supplements: joint-health and skin-health formulations
- Beauty-from-within supplements positioned for skin elasticity
- Pharmaceutical applications: parenteral nutrition
- Pharmaceutical synthesis: ACE inhibitor intermediates and other drug precursors
- Clinical nutrition formulas
- Pet food and pet supplement applications
- Animal feed: specialty applications including aquaculture
- Cosmetic skincare: collagen-positioning formulations
Technical data
| Item | Specification |
|---|---|
| Appearance | White crystalline powder |
| Assay (dry basis) | 98.5% to 101.0% |
| Specific rotation | −84.0° to −86.5° |
| Loss on drying | ≤ 0.3% |
| Residue on ignition | ≤ 0.1% |
| Heavy metals (as Pb) | ≤ 10 mg/kg |
| Chloride | ≤ 0.05% |
| Particle size | Per customer specification |
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