Description
An essential amino acid required for protein synthesis and the precursor for histamine, carnosine, and other biologically important compounds. Used in pharmaceutical applications, infant formula, and as a buffer in biotechnology formulations.
White crystalline powder. Slightly water-soluble; freely soluble in acid solutions.
We supply food-grade and pharmaceutical-grade L-Histidine from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production.
Common market grades include Standard Food Grade (FCC compliant), Pharmaceutical Grade meeting BP/USP/EP/JP specifications, L-Histidine Hydrochloride (alternative salt form), and Biopharmaceutical Grade for protein-formulation buffer applications.
Bulk and reduced-MOQ shipments. Batch-level COA covering assay, specific rotation, related amino acids, heavy metals, and microbiology.
Introduction
L-Histidine is an essential amino acid for infants (conditionally essential for adults) and serves as the precursor for several biologically important compounds: histamine (the neurotransmitter and immune mediator), carnosine (the muscle dipeptide), and the imidazole ring of nucleotide cofactors.
Industrial production proceeds by submerged aerobic fermentation using engineered Escherichia coli or Corynebacterium glutamicum strains.
Recognized as a permitted food ingredient by the U.S. FDA, the European Food Safety Authority, and equivalent regulators worldwide. Listed in BP, USP, EP, and JP pharmacopoeias.
The molecule's pKa near physiological pH (approximately 6.0) makes it valuable as a buffer in biotech and pharmaceutical applications, particularly for monoclonal antibody formulation where histidine buffer outperforms alternative buffers in protein stability across freeze-thaw and lyophilization cycles. This biotech application has grown substantially since 2010.
Strategic positioning combines pharmaceutical and biotech applications (the highest unit value, fastest-growing segments) with infant formula fortification, clinical nutrition, and dietary supplement applications.
Where it is used
- Pharmaceutical applications: parenteral nutrition formulas and monoclonal antibody formulation buffer (the latter is a rapidly growing biotech application)
- Infant formula fortification: mandatory in many regulated markets because histidine is essential for infant growth
- Clinical nutrition: post-surgical and catabolic-state recovery formulas
- Dietary supplements: amino-acid and joint-support formulations
- Sports nutrition products
- Pet food fortification
- Specialty biotech and pharmaceutical buffer applications
Technical data
| Item | Specification |
|---|---|
| Appearance | White crystalline powder |
| Assay (dry basis) | 98.5% to 101.0% |
| Specific rotation | +12.0° to +12.8° |
| Loss on drying | ≤ 0.3% |
| Residue on ignition | ≤ 0.1% |
| Heavy metals (as Pb) | ≤ 10 mg/kg |
| Chloride | ≤ 0.05% |
| Particle size | Per customer specification |
Ready to discuss business?
Send us your spec and requirement. We will respond with availability and pricing within 24 hours.