Description
The standardized polysaccharide extract of Shiitake mushroom (Lentinula edodes), containing lentinan and related beta-glucans as the principal active fraction. Used in immune-support dietary supplements and as a pharmaceutical-grade adjunct therapy in some markets.
Light tan to brown free-flowing powder. Water-soluble.
We supply food-grade Lentinula Edodes Polysaccharide from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production. Organic-certified grades are available.
Common market grades include 10 percent Polysaccharides (cost-effective baseline), 30 percent Polysaccharides (standard supplement grade), 50 percent Polysaccharides (premium grade), and Pure Lentinan (pharmaceutical-grade isolated beta-glucan-cosmetic-grade-oat" class="underline" style="color: var(--sage-deep); text-decoration-color: var(--sage-deep);">beta-glucan used as injectable adjunct therapy in some Asian markets).
Bulk and reduced-MOQ shipments. Batch-level COA covering total polysaccharides (UV), beta-glucan content (Megazyme), residual solvents, heavy metals, and microbiology.
Introduction
Shiitake has been used as both food and medicine in East Asian cultures for over 1,000 years. The mushroom is the second-most-cultivated edible mushroom worldwide and the beta-glucan lentinan was isolated in 1969 in Japan.
Industrial production proceeds by hot-water extraction of dried Shiitake fruiting bodies or mycelium, followed by ethanol precipitation of polysaccharides, chromatographic purification, and spray-drying. Pharmaceutical-grade lentinan undergoes additional purification for parenteral applications.
Recognized as a permitted food ingredient by the U.S. FDA (GRAS), the European Food Safety Authority, and equivalent regulators worldwide. Lentinan is approved as an injectable adjunct cancer therapy in Japan since 1985.
The beta-glucan polysaccharides activate innate immune system pattern-recognition receptors including Dectin-1 and Toll-like receptor 4, supporting the immune-modulation positioning. Clinical evidence for oral supplementation is moderate; the injectable pharmaceutical application has stronger clinical evidence for cancer adjunct therapy.
Strategic positioning combines immune-support dietary supplements globally, pharmaceutical adjunct therapy in regulated Asian markets, and functional food fortification.
Where it is used
- Immune-support dietary supplements: the dominant commercial application globally
- Pharmaceutical applications: lentinan as injectable adjunct therapy in cancer treatment in Japan and several Asian markets
- Functional foods and beverages: immune-positioning fortification
- Traditional Asian medicine product formulations
- Premium pet supplements positioned for immune health in senior animals
- Sports nutrition: recovery and immune-support positioning
- Cardiovascular-support supplements (shiitake has been studied for cholesterol)
Technical data
| Item | Specification |
|---|---|
| Appearance | Light tan to brown free-flowing powder |
| Total polysaccharides (UV) | 10% / 30% / 50% (grade dependent) |
| Beta-glucans (Megazyme) | ≥ 25% |
| Loss on drying | ≤ 6.0% |
| Residue on ignition | ≤ 8.0% |
| Heavy metals (as Pb) | ≤ 2 mg/kg |
| Total plate count | ≤ 10000 cfu/g |
| Source | Lentinula edodes fruiting body or mycelium |
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