Description
The hydrochloride salt of Berberine, a quaternary ammonium alkaloid extracted primarily from Berberis aristata (Indian Barberry), Coptis chinensis (huang lian), or Phellodendron species. Used in blood-sugar-management and metabolic-health dietary supplements globally, with one of the strongest clinical evidence bases for any plant alkaloid in metabolic applications.
Bright yellow to yellow-brown crystalline powder with characteristic bitter taste. Sparingly water-soluble at room temperature.
We supply food-grade Berberine HCl from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production.
Common market grades include 97 percent Berberine HCl (the standard supplement grade), 98 percent Berberine HCl (premium grade matching USP specifications), 99 percent Berberine HCl (pharmaceutical grade), Berberine Sulfate (alternative salt form), and Dihydroberberine (the bioavailability-enhanced reduced form).
Bulk and reduced-MOQ shipments. Batch-level COA covering berberine content (HPLC), related alkaloid impurities (palmatine, jatrorrhizine), residual solvents, heavy metals, pesticides, and microbiology.
Introduction
Berberine has been used in Traditional Chinese Medicine (huang lian) and Ayurveda (Indian Barberry) for over 2,500 years for gastrointestinal complaints, infections, and heat-clearing applications. The compound has emerged as one of the most clinically-studied natural metabolic-support ingredients globally over the past two decades.
Industrial production proceeds by acid extraction of dried Berberis or Coptis roots, followed by crystallization, purification, and conversion to the hydrochloride salt for improved stability and dosing accuracy.
Recognized as a permitted food ingredient in most jurisdictions. In the EU, Berberine has been the subject of Novel Food review with specific use restrictions in some categories.
Clinical evidence for Berberine in type 2 diabetes management is among the strongest for any natural-product supplement ingredient, with multiple systematic reviews showing efficacy comparable to first-line oral hypoglycemic medications at 1500 mg per day. Additional clinical evidence supports cholesterol management and modest weight-loss effects.
Strategic positioning is dominated by blood-sugar and metabolic-health dietary supplements globally, with premium positioning supported by one of the strongest natural-product clinical evidence bases.
Where it is used
- Blood-sugar-management dietary supplements: diabetes-support and glucose-disposal formulations (the dominant commercial application)
- Cholesterol and lipid-management supplements
- Weight-management and metabolic-syndrome support formulations
- Gut-health supplements: antimicrobial and SIBO-support positioning
- Traditional Chinese Medicine: huang lian formulations and modern granule formats
- Pharmaceutical applications: registered antidiarrheal medicine in several markets
- Sports nutrition: glucose-disposal and metabolic-flexibility positioning
- Veterinary applications for blood-sugar and gut-health support
Technical data
| Item | Specification |
|---|---|
| Appearance | Bright yellow to yellow-brown crystalline powder |
| Berberine HCl content (HPLC) | 97% / 98% / 99% (grade dependent) |
| Related alkaloids (palmatine, jatrorrhizine) | ≤ 2.0% total |
| Loss on drying | ≤ 8.0% |
| Residue on ignition | ≤ 0.1% |
| Heavy metals (as Pb) | ≤ 2 mg/kg |
| Total plate count | ≤ 1000 cfu/g |
| Source | Berberis aristata, Coptis chinensis, or Phellodendron species roots |
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