Description
A dihydrochalcone glycoside isolated primarily from apple tree bark, leaves, and unripe fruit. Standardized to phloridzin (phlorizin) content. The compound is the historical archetype of SGLT2 inhibitors, having served as the structural model for development of pharmaceutical SGLT2 inhibitors used in type 2 diabetes therapy.
Off-white to pale yellow free-flowing powder. Limited water solubility; freely soluble in alcohol.
We supply food-grade Apple Phloridzin from manufacturers in China holding ISO, Halal, Kosher and other certifications relevant to the product and production.
Common market grades include 10 percent Phloridzin (cost-effective baseline), 40 percent Phloridzin (standard supplement grade), 80 percent Phloridzin (premium grade), and 98 percent Pure Phloridzin (pharmaceutical research grade).
Bulk and reduced-MOQ shipments. Batch-level COA covering phloridzin content (HPLC), residual solvents, heavy metals, pesticides, and microbiology.
Introduction
Phloridzin was first isolated from apple tree bark in 1835 and became one of the earliest characterized natural glycosides. The compound was historically used to induce experimental glycosuria in animal models, leading to the recognition that selective SGLT2 inhibition could be a viable diabetes therapy. Modern pharmaceutical SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin) were developed from phloridzin as the structural starting point.
Industrial production proceeds by ethanol extraction of apple tree bark, leaves, or unripe apple fruit (which contains the highest phloridzin concentrations), followed by chromatographic purification and crystallization to defined purity grades.
Recognized as a permitted food ingredient in most jurisdictions when sourced from apple. Phloridzin itself is not approved as a pharmaceutical drug; it serves only as a research tool and as a dietary supplement ingredient.
Clinical evidence in the supplement context is limited; pharmaceutical SGLT2 inhibitor data does not directly translate to the food-supplement compound due to differences in oral bioavailability and dosing. Strategic positioning targets premium blood-sugar-support and metabolic-wellness supplements where the SGLT2-related mechanism positioning supports premium price points despite limited direct clinical evidence.
Where it is used
- Blood-sugar-support and metabolic-health dietary supplements
- Weight-management supplements positioned around glucose regulation
- Pharmaceutical research applications: the structural basis for SGLT2 inhibitor drug development
- Natural antioxidant in food and beverage applications
- Cosmetic skincare: antioxidant and anti-aging formulations
- Functional beverages: blood-sugar-support and metabolic-wellness drinks
- Hair-care formulations (research applications around 5-alpha reductase inhibition)
Technical data
| Item | Specification |
|---|---|
| Appearance | Off-white to pale yellow free-flowing powder |
| Phloridzin content (HPLC) | 10% / 40% / 80% / 98% (grade dependent) |
| Loss on drying | ≤ 5.0% |
| Residue on ignition | ≤ 5.0% |
| Heavy metals (as Pb) | ≤ 2 mg/kg |
| Total plate count | ≤ 1000 cfu/g |
| Source | Malus domestica bark, leaves, or unripe fruit |
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